Bcl-2-associated death promoter
BCL2-antagonist of cell death

Größe 168 aa; 18,4 kDa
Struktur Heterodimer
Bezeichner
Gen-Namen BAD; BBC2; BCL2L8
Externe IDs OMIM603167   MGI1096330
Vorkommen
Übergeordnetes Taxon Eutheria (Höhere Säugetiere)
Orthologe
Mensch Maus
Entrez 572 12015
Ensembl ENSG00000002330 ENSMUSG00000024959
UniProt Q92934 Q3TFU7
Refseq (mRNA) NM_004322 NM_007522
Refseq (Protein) NP_004313 NP_031548
Genlocus Chr 11: 63.79 - 63.81 Mb Chr 19: 7.01 - 7.02 Mb
PubMed Suche [1] [2]

Bcl-2-Antagonist of Cell Death (BAD) ist ein pro-apoptotisches Protein der Bcl-2-Familie.[1]

Seine Wirkung entfaltet es dadurch, dass es ein apoptose-inhibierendes Protein bindet und deaktiviert. Wenn BAD von der Proteinkinase B phosphoryliert wird (in einem Signalweg durch PI 3-Kinase initiiert), kann es das apoptose-inhibierende Protein nicht mehr binden.

Quellen

  1. Yang et al.:Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995;80(2):285-91. PMID 7834748

Siehe auch


Wikimedia Foundation.

Schlagen Sie auch in anderen Wörterbüchern nach:

  • Bcl-2-associated death promoter — The Bcl 2 associated death promoter (BAD) protein is a pro apoptotic member of the Bcl 2 gene family which is involved in initiating apoptosis. It does not contain a C terminal transmembrane domain for outer mitochondrial membrane and nuclear… …   Wikipedia

  • Death-associated protein 6 — Death domain associated protein Identifiers Symbols DAXX; BING2; DAP6; EAP1; MGC126245; MGC126246 External IDs …   Wikipedia

  • Death-inducing signaling complex — Signaling pathway of TNF R1. Dashed grey lines represent multiple steps The death inducing signaling complex or DISC is a multi protein complex formed by members of the death receptor family of apoptosis inducing cellular receptors.[1] A typical… …   Wikipedia

  • MUC1 — Mucin 1, cell surface associated SEA Domain of MUC1. PDB rendering based on 2acm …   Wikipedia

  • S100A10 — S100 calcium binding protein A10 Crystallographic structure of the p11 protein dimer (cyan and green) complexed with the N terminus of annexin II (magenta) based on the PDB …   Wikipedia

  • MCL1 — Myeloid cell leukemia sequence 1 (BCL2 related) PDB rendering based on 2nl9 …   Wikipedia

  • Caspase-9 — Caspase 9, apoptosis related cysteine peptidase PDB rendering based on 1jxq …   Wikipedia

  • Cytochrome c — Cytochrome c, somatic Three dimensional structure of cytochrome c (green) with a heme molecule coordinating a central Iron atom (orange) …   Wikipedia

  • Tumor necrosis factor receptor — TNFR/NGFR cysteine rich region Structure of the soluble human 55 kd TNF receptor human TNF beta complex[1]. Identifiers Symbol …   Wikipedia

  • YWHAQ — Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide, also known as YWHAQ, is a human gene. PBB Summary section title = summary text = This gene product belongs to the 14 3 3 family of proteins which mediate… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”