Tyrosinkinase Fyn

Tyrosinkinase Fyn
Tyrosinkinase Fyn

Masse/Länge Primärstruktur 537 Aminosäuren
Kofaktor Mn2+
Isoformen B, T, P06421-3
Gen-Name FYN
Externe IDs OMIM137025 UniProtP06241
EC, Kategorie  Tyrosinkinase
Reaktionsart Phosphorylierung von Tyrosinresten in Proteinen
Substrat Xaa-Tyr-Yaa + ATP
Produkte Xaa-TyrP-Yaa + ADP
Übergeordnetes Taxon Wirbeltiere[1]

Die Tyrosinkinase Fyn ist ein Enzym in Wirbeltieren, das die Phosphorylierung mehrerer Proteine an der Aminosäure Tyrosin katalysiert (Tyrosinkinase). Diese Reaktion ist Teil von etwa einem Dutzend Signalwege, die unentbehrlich für die Embryonalentwicklung des Gehirns und dessen spätere Funktion sind. Beim Mensch kontrolliert Fyn das Wachstum der Axone und den Calciumgehalt von Zellen. Von den drei bekannten Isoformen wird 'B' besonders im Gehirn und 'T' in T-Zellen exprimiert.[2]


Für FYN wurden einige Interaktionen mit anderen Proteinen nachgewiesen.


Quellen, Zitatnachweise, Zeitschriftenartikel

  1. Orthologe bei OMA
  2. UniProt P06421
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