Anaphase-promoting complex
Übergeordnet
Nukleäre Ubiquitin-Ligasen
Zellkern
Gene Ontology
AmiGO QuickGO
Anaphase-promoting complex

Enzymklassifikation
EC, Kategorie 6.3.2.19  Ligase (Peptidsynthase)
Produkte Protein-N-Ubiquityllysin

Der Anaphase-promoting complex (APC) - der Anaphase fördernde Komplex oder das Cyclosom - ist ein Enzymkomplex aus der Familie der Ubiquitin-Ligasen, das den zeitlichen Ablauf der Zellteilung (Mitose) steuert.

Durch Anheften von Ubiquitinresten an Substrate markiert sie diese zum enzymatischen Proteinabbau (Proteolyse) durch das 26S-Proteasom.

Zu den bekanntesten Substraten des Enzyms zählen Cyclin-A, Cyclin-B und Securin, an die während der Mitose in einer zeitlich strikt eingehaltenen Folge Ubiquitin angelagert wird, wodurch sie schließlich abgebaut werden. APC ist damit der molekulare Hauptregulator für den zeitlichen Ablauf der Mitose. Im menschlichen Genom sind einige Hundert Ubiquitinligasen kodiert, was diese zur bisher größten Gruppe von Enzymen macht.


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  • Anaphase-promoting complex — Anaphase Promoting Complex, also called cyclosome (APC/C), is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2)… …   Wikipedia

  • anaphase-promoting complex — noun A complex of several proteins which is activated during mitosis to initiate anaphase Syn: cyclosome …   Wiktionary

  • Anaphase — Anaphase, from the ancient Greek ἀνά (up) and φάσις (stage), is the stage of mitosis when chromosomes separate in a eukaryotic cell. Each chromatid moves to opposite poles of the cell, the opposite ends of the mitotic spindle, near the… …   Wikipedia

  • Maturation promoting factor — (abbreviated MPF, also called mitosis promoting factor or M Phase promoting factor) is a heterodimeric protein composed of cyclin B and cyclin dependent kinase (CDK1, also known as Cdc2 or p34 kinase) that stimulates the mitotic and meiotic cell… …   Wikipedia

  • ANAPC2 — Anaphase promoting complex subunit 2, also known as ANAPC2, is a human gene.cite web | title = Entrez Gene: ANAPC2 anaphase promoting complex subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=29882| …   Wikipedia

  • ANAPC5 — Anaphase promoting complex subunit 5, also known as ANAPC5, is a human gene.cite web | title = Entrez Gene: ANAPC5 anaphase promoting complex subunit 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51433| …   Wikipedia

  • ANAPC4 — Anaphase promoting complex subunit 4, also known as ANAPC4, is a human gene.cite web | title = Entrez Gene: ANAPC4 anaphase promoting complex subunit 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=29945| …   Wikipedia

  • ANAPC1 — Anaphase promoting complex subunit 1, also known as ANAPC1, is a human gene.cite web | title = Entrez Gene: ANAPC1 anaphase promoting complex subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=64682| …   Wikipedia

  • ANAPC7 — Anaphase promoting complex subunit 7, also known as ANAPC7, is a human gene.cite web | title = Entrez Gene: ANAPC7 anaphase promoting complex subunit 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51434| …   Wikipedia

  • ANAPC10 — Anaphase promoting complex subunit 10, also known as ANAPC10, is a human gene.cite web | title = Entrez Gene: ANAPC10 anaphase promoting complex subunit 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

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